Early upregulation of endothelial adhesion molecules in obese hypertensive men.

P27: KCNK2 and Adhesion Molecules in an in-Vitro Blood Brain Barrier Model

Two-pore domain potassium channels, like KCNK2, are known to play an important role in inflammatory diseases such as multiple sclerosis (MS). Upregulation of cellular adhesion molecules in mouse brain microvascular endothelial cells (MBMECs) of Kcnk2-/- mice resulted in elevated leukocyte trafficking into the central nervous system under inflammatory conditions. The current project aims to gain...

Investigation of the Changes in Serum Intercellular and Vascular Adhesion Molecules (ICAM-1 and VCAM-1) and Nitric Oxide Levels in Response to Exercise Training and L-arginine Supplementation in Postmenopausal Hypertensive Women

O 7: KCNK2 Regulates the Nanoscale Formation of Immune Docking Structures on Brain Endothelial Cells Under Autoinflammatory Conditions

KCNK2 was previously shown to regulate immune-cell trafficking into the central nervous system (CNS). Kcnk2-/- mice demonstrated a more severe disease course in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, due to an increased immune-cell migration into the CNS. An upregulation of the cellular adhesion molecules ICAM1 and VCAM1 on brain endothelial cells in K...

Plasma vascular endothelial growth factor as a marker for early vascular damage in hypertension.

Elevation of plasma VEGF (vascular endothelial growth factor) has been noted in patients with hypertension or atherosclerosis. VEGF has been regarded as a marker for endothelial dysfunction. However, the role of VEGF in hypertension-induced vascular injury and its relationship with endothelial function have not been studied. This study included 20 untreated hypertensive men with grade 1 or 2 hy...

Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex.

The expression of intercellular adhesion molecule 1 (ICAM-1) was studied in rat focal ischemic cortex. A significant increase in ICAM-1 mRNA expression in the ischemic cortex over levels in contralateral (nonischemic) site was observed by means of Northern blot analysis following either permanent or temporary occlusion with reperfusion of the middle cerebral artery (PMCAO or MCAO with reperfusi...